ChemPharma® Professional Association
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Cvetovich, Ray Ph.D.
RJC Process Chemistry Consulting, LLC
API Synthesis, Process Chemistry and Development
- Process Research Chemistry and Development
- Technical Transfers to CMOs
- Processing scale-up issues, problem solving, defining critical process parameters
- Managing CRO process research
- Reaction development and optimization
- Crystallization processes for API and critical intermediates
Specializing in process research expertise and practical technical advice in solving and avoiding problems in your API synthesis so that your process is both robust and scaleable
Process Research and Development
Designing, evaluating and managing synthetic route development to API and intermediates for long term and short term requirements, focusing on: costs, scalability, robustness, and safety.
Trouble shooting and problem solving scale-up issues
Reaction optimization and improvement (yield, productivity, reagents, time cycles, exotherm control, kinetics, by-product formation, safety)
Design of experiments (DoE) to evaluate and define operating conditions and critical process parameters (CPP’s)
Crystallization development of polymorphs, solvates, hydrates, and salts of API and critical intermediates
Chiral chemistry, resolutions, racemization/resolution, dynamic resolutions, catalytic reactions
Support of data analysis: HPLC, GC, LCMS, NMR, DSC, XRPD, TG, KF, titrations
Writing and review of technical transfer and CMC documents, and patents
Contract Laboratory Work
Oversight and performance review of CMO operations
Managing and review of CRO efforts for process development
Writing and coordination of CMC chemistry and analytical data
Available to work within your laboratories for process development or CMC issues
Training Seminars and Lectures
Aspects of process development, critical process parameters, developing reactions and crystallizations, and solving scale-up issues
Seminars on real world process chemistry project experiences
329 Fawnridge Drive
Scotch Plains NJ 07076
Phone: (908) 285-9078